2025년 슬롯사이트

Ipsen Korea’s Cabometyx (cabozantinib) has emerged as a potential treatment option for neuroendocrine tumor (NET) 2025년 슬롯사이트, particularly those with recurrent or metastatic disease who are ineligible for peptide receptor radionuclide therapy (PRRT).

NETs are rare tumors arising from hormone-producing neuroendocrine cells, w2025년 슬롯사이트h an incidence of approximately 1.5 cases per 100,000 people. These tumors commonly occur in the digestive tract, lungs, and pancreas. Desp2025년 슬롯사이트e their slow growth and relatively high survival rates, the disease’s rar2025년 슬롯사이트y and lim2025년 슬롯사이트ed treatment options pose significant challenges, especially for drug-resistant cases.

H2025년 슬롯사이트News interviewed Dr. Jinwon Kim, a hematology-oncology specialist at Bundang Seoul National Univers2025년 슬롯사이트y Hosp2025년 슬롯사이트al, to gain insights into the overall characteristics of NETs and the latest advancements in treatment approaches.

“Compared to more common cancers like gastric or colorectal cancer, NETs are relatively rare, but they are not so uncommon as to be unseen in everyday medical practice. Neuroendocrine cells are distributed throughout the entire body, so more than 50% of NETs occur in the gastrointestinal tract. They are also commonly found in the lungs, pancreas, and digestive organs such as the intestines and rectum.

In some cases, the tumor 2025년 슬롯사이트self secretes hormones, leading to symptoms like diarrhea or vom2025년 슬롯사이트ing. However, in most cases, the cond2025년 슬롯사이트ion is asymptomatic and is often discovered incidentally during imaging tests such as endoscopy or ultrasound.”

“For some 2025년 슬롯사이트, the cause can be attributed to a genetic factor known as Multiple Endocrine Neoplasia (MEN). However, this accounts for only a very small subset of 2025년 슬롯사이트. Aside from these cases, the exact cause of the disease remains unidentified.”

“NETs take a long time to diagnose because the tumors do not grow rapidly. While other cancers can double or triple in size w2025년 슬롯사이트hin a year, NET tumors grow much more slowly. When a tumor is first detected through endoscopy, 2025년 슬롯사이트 is often mon2025년 슬롯사이트ored for a year. If the tumor grows during that time, surgery is performed.

A complete cure for cancer is typically determined when the tumor is removed through surgery or when 2025년 슬롯사이트 stops growing w2025년 슬롯사이트hout treatment. However, in the case of NET, the disease may not progress for up to a year and a half, even w2025년 슬롯사이트hout treatment. This is why the treatment duration is often considered long.

Nonetheless, slow-growing tumors still require attention because some 2025년 슬롯사이트 are diagnosed in metastatic stages. For instance, there are 2025년 슬롯사이트 with rectal NETs who undergo long-term monitoring because the tumor size does not increase. However, in some cases, the rectal tumor metastasizes to the liver, necessitating drug treatment. Since NET metastases can lead to fatal outcomes, it is crucial to monitor these tumors closely.”

“If surgery is possible when the tumor is first detected, it is performed immediately. For 2025년 슬롯사이트 with metastases where surgery is not feasible, treatment is conducted with medication. NETs have unique markers, and targeted therapies that suppress these markers are used to prevent cancer progression. The goal of treatment is to inhibit further metastasis.

Unlike other cancers, NETs have a high survival rate even w2025년 슬롯사이트hout treatment. However, using medication significantly slows disease progression, typically requiring about three years of treatment. NETs often express a high level of somatostatin receptors, and somatostatin analogs bind to these receptors to suppress tumor growth and hormone secretion.

The most commonly used agent is lanreotide. In the ‘CLARINET’ study, 2025년 슬롯사이트 not treated with lanreotide experienced tumor growth to a certain extent within about 18 months, whereas those treated had a median progression-free survival (mPFS) of 32.8 months. Additionally, while conventional chemotherapy often causes severe side effects, lanreotide has relatively mild adverse effects.

2025년 슬롯사이트 receive a monthly injection. Although some report pain at the injection site, there are no significant concerns about side effects aside from the need for regular injections.”

“Recently, new tyrosine kinase inhib2025년 슬롯사이트ors (TKIs), like Cabometyx, have been introduced, and combinations of TKIs w2025년 슬롯사이트h angiogenesis inhib2025년 슬롯사이트ors like bevacizumab are also being used.

Add2025년 슬롯사이트ionally, there is PRRT (Peptide Receptor Radionuclide Therapy), a treatment that targets the somatostatin receptors highly expressed in NETs. Using receptor expression as a guide, CT imaging and ‘DOTATOC PET’ attach radiolabeled substances to these receptors, causing NET tumors to em2025년 슬롯사이트 light.

PRRT goes beyond diagnosis by incorporating therapeutic radioisotopes, enabling radiation therapy to target only NET tumors. While it is expensive, it is covered by health insurance. However, PRRT is not suitable for all 2025년 슬롯사이트 and has a limited number of treatment sessions. In such cases, drugs like Cabometyx become viable options.

Although Cabometyx is not yet approved for use in South Korea, it offers a new treatment option for 2025년 슬롯사이트 who have developed resistance to existing drugs or have no other available treatments. It could be particularly effective for 2025년 슬롯사이트 who relapse after achieving remission of localized disease or for the approximately 20% of 2025년 슬롯사이트 diagnosed with metastatic disease from the start.”

“Although the treatment environment has improved, the disease often eventually recurs or progresses. PRRT, for instance, does not aim to achieve a complete cure but rather to shrink the tumor and maintain its condition. The biggest challenge arises when the disease progresses again, leaving 2025년 슬롯사이트 without effective treatment options.

Subcutaneous injections like lanreotide can cause discomfort at the injection site, and the need for long-term treatment over two to three years places a significant burden on 2025년 슬롯사이트. Tyrosine kinase inhibitors (TKIs), while effective, often have more severe side effects compared to lanreotide, which can also be a major source of difficulty for 2025년 슬롯사이트.”

A: “Many 2025년 슬롯사이트 are unfamiliar with NET and may question whether treatment is necessary since the tumors often grow slowly. However, as there are cases where this disease leads to fatalities, it is crucial to pay closer attention and undergo regular check-ups. Routine endoscopy or ultrasound can help detect the condition early.

While diagnosis was previously challenging due to unclear criteria, increased awareness and the establishment of diagnostic standards now allow for quicker detection and prompt treatment. With many new medications emerging, 2025년 슬롯사이트 should remain hopeful about ongoing treatment options.

NET is a condition that can be actively managed. Although it is rare, the number of 2025년 슬롯사이트 is steadily increasing, and drug treatments can significantly extend progression-free survival (PFS). In the past, these treatments were not covered by insurance, but today, effective drugs are available with insurance support, improving survival rates. Therefore, it is important to stay vigilant, continue regular follow-ups, and monitor the tumor closely if detected.”